Excited to announce the launch of SPRAVATO®..... Click Here to Learn More →

SPRAVATO® (esketamine) is a groundbreaking nasal spray approved by the FDA for adults struggling with two challenging types of depression:

Treatment-Resistant Depression (TRD): Designed for individuals who have not responded to at least two different antidepressants.

Major Depressive Disorder (MDD) with Acute Suicidal Ideation or Behavior: A rapid-acting option for individuals experiencing intense symptoms and an urgent need for stabilization.
Unlike traditional oral antidepressants that may take weeks to work, SPRAVATO® has been shown to deliver symptom relief in as little as 24 hours.
What to Expect During Spravato Treatment
SPRAVATO® operates differently from standard treatments by acting on NMDA receptors in the brain. This novel approach helps reset neural pathways that contribute to depression. Administered in our certified treatment center at Tennessee Ketamine & Wellness Center, patients self-administer the nasal spray under clinical supervision and remain on-site for observation for a minimum of two hours to ensure safety.
Ask the Experts
Spravato Patient Testimonial


Start with a paid phone consultation, with the cost applied toward your infusion if you move forward with treatment. If eligible, you'll meet with our mental health professionals for a full evaluation and medical history review. We’ll also verify insurance coverage to avoid surprises.

After approval, your SPRAVATO® sessions will be scheduled at our clinic. You’ll self-administer the spray in a calm, comfortable environment while monitored by our staff for at least two hours.

Treatment begins with an induction phase (typically two sessions weekly) and transitions to maintenance dosing. We customize frequency based on your individual progress and needs.

Our care team is with you every step of the way. We offer regular follow-ups, collaborate with your existing mental health providers, and continuously adapt your care plan.

Week 1-4
2 Treatments a Week

Week 5-8
1 Treatments a Week

Week 9+
1 Treatments a Week Every 1-2 Weeks
Response Rate:
Conventional antidepressant medications generally yield positive treatment responses in about 40% to 60% of patients. In contrast, clinical research on SPRAVATO® (esketamine) has reported response rates reaching up to 70% (Popova et al., 2019, American Journal of Psychiatry).
Onset of Therapeutic Effect:
Whereas standard antidepressants may require between four to six weeks before users begin to notice any significant improvement, esketamine (SPRAVATO®) has been associated with symptom relief in as little as 24 hours, according to clinical trial data (BMC Psychiatry, 2022).
Sustained Remission Rates:
In a clinical trial, 43.8% of individuals who continued treatment with Spravato alongside an oral antidepressant at the three-month mark had entered remission from major depressive episodes.




We follow only FDA-approved treatment protocols.

Our clinic spaces are designed to support mental wellness.

We engage your existing care team to ensure consistent and holistic support.

We work with your insurance and handle all necessary paperwork.
No. SPRAVATO® must be administered in a clinical setting under supervision.
Download our informational materials to learn more about SPRAVATO® and how it may benefit your recovery journey.
We know how busy life can be, so we offer the option of contacting you based on your preferences to discuss Spravato® treatment. Please call us or provide your information below and we will contact you in the timeframe that you choose.
Tennessee Ketamine & Wellness Center in Franklin serves patients looking for advanced depression treatment options, including ketamine infusion therapy and SPRAVATO®, from Franklin and nearby communities throughout the surrounding area.