Excited to announce the launch of SPRAVATO®..... Click Here to Learn More →
Excited to announce the launch of SPRAVATO®..... Click Here to Learn More →
If you’re searching for advanced options to treat depression—especially when traditional medications haven’t worked—you’re not alone. At Tennessee Ketamine & Wellness Center, we’re proud to offer innovative, evidence-based treatments designed to support individuals living with treatment-resistant depression (TRD) and major depressive disorder (MDD).
One of the most significant advancements in modern depression care is Spravato®, an FDA-approved esketamine nasal spray. Below, we’ll explain what Spravato is, how esketamine works, who may benefit, and how this therapy fits into a comprehensive mental wellness plan under expert medical supervision.
Spravato® is a prescription nasal spray containing esketamine, a refined form of ketamine that has been approved by the U.S. Food and Drug Administration (FDA). It is indicated for:
Unlike standard antidepressants that may take weeks to show results, Spravato has demonstrated the potential for rapid symptom relief, particularly in patients who have not responded adequately to other treatments.
Esketamine works differently than conventional antidepressants. Rather than primarily targeting serotonin or norepinephrine, Spravato acts on the brain’s glutamate system, which plays a key role in neural communication and synaptic plasticity.
By modulating glutamate pathways, esketamine may help restore and strengthen neural connections associated with mood regulation. This unique mechanism is believed to contribute to faster and more robust improvements in depressive symptoms, making Spravato a valuable option for individuals who feel “stuck” after trying multiple medications.
Spravato may be appropriate for adults who:
Eligibility is determined through a thorough medical and psychiatric evaluation. At Tennessee Ketamine & Wellness Center, every patient is carefully assessed to ensure Spravato is both safe and clinically appropriate.
At Tennessee Ketamine & Wellness Center, we proudly serve patients throughout Franklin and surrounding Middle Tennessee communities. Our clinic offers FDA-approved Spravato® (esketamine) treatment for individuals struggling with treatment-resistant depression and major depressive disorder, all under strict REMS-certified medical supervision.
Patients travel to us from nearby cities and neighborhoods within a 20-mile radius of Franklin, TN, including:
If you’re searching for Spravato near Franklin, esketamine therapy in Middle Tennessee, or a medically supervised alternative for depression when traditional medications haven’t worked, our team is here to help.
At Tennessee Ketamine & Wellness Center, patient safety, clinical excellence, and individualized care are our top priorities. Our programs are overseen by Randall Malchow, M.D., Medical Director, who brings extensive clinical experience and a patient-centered approach to care.
Spravato is offered as part of a broader treatment strategy and is not a replacement for IV ketamine therapy. Instead, it may serve as a complementary option depending on a patient’s diagnosis, medical history, response to prior treatments, and long-term wellness goals.
What to Expect During Treatment
This structured, supervised environment ensures both safety and therapeutic effectiveness.
Spravato® carries important safety considerations. Possible side effects may include:
Because esketamine has the potential for abuse or misuse, all patients are closely monitored during and after treatment. Spravato is not recommended during pregnancy, and ongoing assessment for suicidal thoughts or behaviors is an essential part of care.
Your medical team will review all risks, benefits, and alternatives with you before treatment begins.
Spravato represents a meaningful advancement in depression treatment, especially for individuals who have struggled to find relief through conventional approaches. By targeting the glutamate system, this FDA-approved esketamine therapy offers a new pathway toward healing—one that may provide faster and more effective symptom improvement for eligible patients.
At Tennessee Ketamine & Wellness Center, we are committed to delivering compassionate, evidence-based care tailored to each individual. Whether you’re exploring Spravato, IV ketamine, or other integrative mental health treatments, our team is here to guide you every step of the way.
Contact us today to schedule a consultation and learn whether Spravato or esketamine-based therapies may be appropriate for your mental health journey.
This content is for informational purposes only and does not constitute medical advice. Spravato® is available only through FDA-certified treatment centers under the REMS program, with on-site administration and monitoring. Please refer to the Full Prescribing Information for complete safety details.
What conditions does Spravato® treat?
Spravato® is FDA-approved to treat treatment-resistant depression (TRD) and major depressive disorder (MDD) with acute suicidal ideation or behavior, when used in combination with an oral antidepressant. It is often considered when standard antidepressants have not provided adequate relief.
How quickly does Spravato® work compared to traditional antidepressants?
Many patients report improvement in depressive symptoms within days to weeks, rather than the several weeks often required for traditional antidepressants. Individual responses vary, and results depend on medical history and treatment adherence.
What is the difference between Spravato® and IV ketamine?
Spravato® contains esketamine, a derivative of ketamine, and is FDA-approved with strict REMS requirements. IV ketamine is used off-label and delivered intravenously. At Tennessee Ketamine & Wellness Center, both options may be discussed depending on patient needs, diagnosis, and response history.
Is Spravato® safe?
Spravato® has been studied extensively and approved by the FDA. Because it may cause sedation, dissociation, or temporary blood pressure increases, it is administered only in a certified medical setting with continuous monitoring before discharge.
How often will I need Spravato® treatments?
Most treatment plans begin with twice-weekly sessions during the induction phase, followed by weekly or bi-weekly maintenance sessions. Your exact schedule will be determined by your provider based on your response and clinical progress.
Can I drive myself home after Spravato® treatment?
No. Due to potential side effects such as sedation or altered perception, patients must arrange transportation home after each Spravato® session and should avoid driving or operating machinery until the next day.
Is Spravato® covered by insurance?
Many commercial insurance plans and some government plans provide coverage for Spravato® when medical criteria are met. Prior authorization is often required. Our team can help verify benefits and guide you through the approval process.
Who should not receive Spravato®?
Spravato® may not be appropriate for individuals with certain medical conditions, including uncontrolled high blood pressure, aneurysms, or a history of hypersensitivity to ketamine or esketamine. It is also not recommended during pregnancy. A thorough medical evaluation is required before starting treatment.
Do I still need to take an antidepressant with Spravato®?
Yes. FDA guidelines require Spravato® to be used in combination with an oral antidepressant. Your provider will work with you to determine the most appropriate medication and dosage.
How do I get started with Spravato® treatment near Franklin, TN?
The first step is scheduling a consultation at Tennessee Ketamine & Wellness Center. Our clinical team will review your history, confirm eligibility, discuss treatment options, and create a personalized care plan.
Tennessee Ketamine & Wellness Center in Franklin, TN provides advanced ketamine infusion therapy and SPRAVATO® treatment for patients throughout the greater Nashville area. Our clinic proudly serves nearby communities seeking compassionate, medically supervised care for depression, treatment-resistant depression, PTSD, anxiety, OCD, and chronic pain conditions.
Conveniently located in Franklin near Cool Springs, our clinic is accessible to patients across Williamson County and the Nashville metro area looking for personalized ketamine therapy or insurance-covered SPRAVATO® treatment options.
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